http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103833842-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-595 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-595 |
| filingDate | 2014-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103833842-B |
| titleOfInvention | A kind of preparation method of sincalide |
| abstract | The present invention relates to polypeptide drugs synthesis technical field, particularly relate to a kind of preparation method of sincalide.The method comprises: solid phase synthesis Fmoc-Phe-resin; According to sincalide peptide sequence, coupling amino acid successively on Fmoc-Phe-resin, obtained sincalide peptide resin; Sincalide peptide resin, through cracking, precipitation, obtains sincalide crude product; Sincalide crude product through dissolving, purifying, turn salt, freeze-drying, to obtain final product.Coupling agent of the present invention can improve coupling effect, reduces because of-Tyr(SOn 3 na) coupling difficulty and produce by-products content.Cracking adopts the mode of salt bath, can prevent coming off of sulfonyl group, and therefore, method provided by the invention can ensure, under the prerequisite that the purity of sincalide product does not reduce, to improve the stability of product.The sincalide yield prepared the invention provides method can reach 42%, purity & gt; 99%; After being mixed with aqueous solution placement 48h, foreign matter content has no showed increased. |
| priorityDate | 2014-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 85.