| abstract |
The present invention relates to a pyrazine derivative represented by formula I or its non-toxic pharmaceutically acceptable salt, hydrate or solvate having anti-RNA virus effect, Wherein, X represents H or a halogen atom; R 1 and R 2 are OR 3 or NHCH(R 4 )COOR 5 ; R 1 and R 2 are the same or different; R 3 represents CH(R 6 )OC(O)R 5 , CH(R 6 )OC(O)OR 5 , aryl or substituted aryl; R 4 represents H, -CH 3 , -CH(CH 3 ) 2 , -CH 2 CH(CH 3 ) 2 , -CH(CH 3 ) (CH 2 CH 3 ), -CH 2 OH, -CH(OH)CH 3 , -CH 2 SH, -CH 2 CH 2 SCH 3 , -CH 2 COOH, -CH 2 CONH 2 , -CH 2 CH 2 COOH, -CH 2 CH 2 CONH 2 , -(CH 2 ) 3 NHC(NH)NH 2 , or -(CH 2 ) 4 NH 2 ; when R 4 is not H, the carbon atom connected to R 4 The absolute configuration is R or S, or RS; R 5 represents C 1 -C 8 alkyl, cycloalkyl, or aryl; R 6 represents H or C 1 -C 5 alkyl; when R 6 is not When H, the absolute configuration of the carbon atom connected to R4 is R or S, or RS. |