http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103833772-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-06 |
| filingDate | 2014-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103833772-B |
| titleOfInvention | A kind of synthetic method of cephalosporin |
| abstract | The present invention relates to the synthetic method of a kind of cephalosporin, it is suitable for cephalo-type chemicals manufacturing enterprise.The preparation method that the invention discloses 7-[(Z)-2-(2-amino-4-thiazolyl)-2-(carboxylic methoxyimino) acetylamino]-3-methyl Cephalosporanic acid, namely under solvent exists with alkali, 7-ADCA and side chain thioester (Z)-(2-(2-aminothiazole-4-base)-2-[tertbutyloxycarbonyl methoxyimino] acetic acid-2-[4-morpholinodithio thioesters) carry out condensation reaction at a certain temperature, through extracting, decolouring can obtain intermediate 7-[(Z)-2-(2-amino-4-thiazolyl)-2-(tertbutyloxycarbonyl methoxyimino) acetylamino]-3-methyl Cephalosporanic acid with acid out crystalline substance again, intermediate uses acid Deprotection again with after alkali dissolution, through decolouring, brilliant with acid out, filter, it is drying to obtain crude product.In view of drug resistance is day by day serious, develop new antibacterial activity thing and manufacture method more, have its necessity. |
| priorityDate | 2014-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.