http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103833717-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-58 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-58 |
| filingDate | 2014-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103833717-B |
| titleOfInvention | A kind of synthetic method of nebivolol hydrochloride |
| abstract | The invention discloses a kind of synthetic method of nebivolol hydrochloride, with 2-amino-1-(the fluoro-2-chromanyl of-6-) ethanol non-enantiomer mixture for starting raw material, first 2-amino-1-(the fluoro-2-chromanyl of-6-) ethanol non-enantiomer mixture is carried out recrystallization separation, obtain corresponding diastereomer A and diastereomer B respectively, by diastereomer B wherein through Reactive Synthesis epoxy compoundss such as diazotization, halogenation and cyclisation, then the epoxy compounds obtained and diastereomer A are obtained by reacting nebivolol hydrochloride.This reaction conditions is gentle, easy and simple to handle, synthetic route is short, is suitable for the industrialized mass production of nebivolol hydrochloride. |
| priorityDate | 2014-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 119.