http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103833553-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d8879615a983dd87fb7eb03b5bd6a72 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C247-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C247-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-08 |
| filingDate | 2010-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ff1199b41f7bb033093181fe7115c41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb358d55b1b68bff42dd57e435286bef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_faa05fdd0f63d04d7e9705caad2d4d98 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_654758a52915dd770db39df6c7cc9d37 |
| publicationDate | 2015-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103833553-B |
| titleOfInvention | Midbody for preparing agomelatine and preparation method thereof |
| abstract | The invention relates to the technical field of a preparation method of carboxylic acid amide, and particularly relates to the technical field of agomelatine and a preparation method of an agomelatine midbody. The invention particularly discloses the agomelatine midbody and a preparation method thereof. The preparation method of the midbody comprises the steps that 1-halogen-7-alkoxy naphthalene is used as a raw material and is subjected to alkylation reaction so as to obtain a compound shown in a formula (2), the obtained compound shown in the formula (2) is subjected to grignard reaction so as to obtain a compound shown in a formula (3), the compound shown in the formula (3) reacts with trifluoroacetic anhydride so as to obtain a compound shown in a formula (4), and the compound shown in the formula (4) is a new midbody compound for synthesizing agomelatine and derivatives thereof; meanwhile the compound shown in the formula (4) reacts with sodium azide so as to obtain a compound shown in a formula (5), which is also a new midbody compound for synthesizing agomelatine and derivatives thereof; and the agomelatine and agomelatine derivatives suitable for industrial production can be obtained through simple reaction such as hydrogenation reaction, electrophilic substitution and the like of the compound shown in the formula (5), wherein in the formula, R is an alkyl radical, and X is F, Cl, Br and I. |
| priorityDate | 2010-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 94.