http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103819551-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 2014-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103819551-B |
| titleOfInvention | The chemical preparation process of Orexin polypeptide and purposes |
| abstract | The invention discloses the chemical scale synthetic method of a kind of orexin polypeptide, it comprises the steps: that (1) uses the Rink Amide Resin thick peptide of method synthesizing linear to prepare resin.(2) enter AA circulation, by the product of step (1) gained, use solid-phase synthesis, synthesize the most one by one, obtain 33 amino acid whose linear thick peptides.(3) by the linear thick peptide of step 2 gained, first form first pair of disulfide bond of 6 and 12 interdigits with hydrogen peroxide oxidation, then utilize iodine preparation directly to form second pair of disulfide bond of 7 and 14 interdigits, obtain the thick peptide solution of orexin of cyclisation.(4) by the thick peptide solution of the orexin separated property HPLC purification of the cyclisation of step 3 gained, turn salt and lyophilization after, obtain orexin polypeptide.(5) utilize Kaiser detection method and HPLC MS method, complete structure and the purity testing of step 4 gained orexin polypeptide.The unique advantages such as owing to orexin polypeptide is normally present in a kind of nerve polypeptide in human body, therefore for the angle developing into medicine, it is little that it has toxic and side effects, and Normal Physiological Function interference is little. |
| priorityDate | 2014-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 112.