| abstract |
The invention discloses a method for synthesizing 7-deaza-7-haloguanosine; the method comprises the following steps: the compound of formula (III) is deprotected under alkaline conditions to obtain the compound of formula (IV1) or (IV2) Compound; further demethylation to obtain the compound of formula (I), that is, the 7-deaza-7-halogenated guanosine; Wherein, R 1 is H or OH, R 2 is I, Br or Cl, R 3 is H or The 7-deaza-7-halogen-guanosine synthesized by the present invention is a basic raw material widely used in biological fields such as DNA sequencing, labeling, and extension. At present, its sales price is very high, and the synthesis method is complicated and difficult to control; However, the raw materials required by the synthesis method of the present invention are simple and easy to obtain, and the synthesis process is all conventional chemical reactions, which can be used for large-scale popularization. |