| abstract |
The present invention relates to the Compounds and methods for for treating the diseases relevant with fluid retention or salt over loading such as fluid retention that such as heart failure (especially congestive heart failure), chronic nephropathy, end-stage renal disease, hepatopathy and Peroxisome proliferators activated receptorsĪ„ (PPAR) gamma agonist induce.The present invention also relates to the Compounds and methods for for treating hypertension.The invention still further relates to for treating disorder of gastrointestinal tract, including the Compounds and methods for treating or alleviating the pain relevant with disorder of gastrointestinal tract.Described method generally comprises the compound that mammal in need casts medicine effective dose, or comprise the medical composition of described compound, sodium ion that described compound or medical composition are designed to substantially to work to suppress wherein NHE mediation in gastrointestinal (GI) road and hydrionic antiport. |