http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103788102-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6ed83b9d5c28c6c356d1d08d58501e7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-107 |
| filingDate | 2014-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a549f66f64cde69356ba88958131420 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c5b47176f59af0d6fe880f79c854250 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1345a5c0cdf5633490329f5baccd831 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0595b52e4d436312d6339f4d82add2c |
| publicationDate | 2014-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103788102-A |
| titleOfInvention | A kind of synthetic method of spiro-epoxy indole butenolide compound |
| abstract | This patent relates to the field of organic chemistry, in particular to a method for synthesizing a spiro-epoxy indole butenolide compound as shown in formula IV. This method takes the alkynal aldehyde shown in formula I and the N-methyl isatin shown in formula II as raw materials, in the presence of triazolium salt, lithium chloride and diisopropylethylamine shown in formula III Under the condition of dioxane as solvent, under the protection of nitrogen and 10-65 ℃, the reaction was carried out for 3-72h, the reaction solution was cooled and concentrated, and the mixed solvent with petroleum ether: acetone volume ratio of 25:1 was used as eluent Column chromatography elutes, collects the eluate part of all detected products, and obtains the spiro-epoxyindole butenolide product after rotary evaporation to remove the solvent. The synthetic method of the invention has the advantages of good yield, wide substrate application, simple operation, mild reaction, convenient post-treatment and the like. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105777688-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111423421-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110698490-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105713001-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111423421-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105713001-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105777688-A |
| priorityDate | 2014-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.