http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103787999-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-04 |
| filingDate | 2013-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103787999-B |
| titleOfInvention | The synthetic method of Irbesartan impurity |
| abstract | Irbesartan impurity A (1 pentanamide cyclopentane ［ 2'(1H tetrazolium 5 base) biphenyl 4 ylmethyl ］ for acid amides) synthetic method, in N (trityl group) 5 (4' bromomethylbiphenyl 2 base) tetrazole, 32% sodium hydroxide solution, TBAB and dichloromethane is added including (1), under stirring, instill 1 (valeryl amido) cyclopentane formamide dichloromethane solution again, wash after reaction, dichloromethane is evaporated off, obtains Irbesartan impurity A.(2) with the Irbesartan impurity A of oxolane dissolving step (1) gained, in room temperature, 0～3% under moisture, in the lower alcohol containing C1～C5, adds chloroacetic chloride and sloughs trityl and prepare Irbesartan impurity A；Dripping saleratus again adjusts pH value neutral, static layering, and oxolane aqueous layer extracted merges oxolane layer, and anhydrous magnesium sulfate is dried, and adds acetone and n-hexane in residue, and stirring separates out crystallization, suction filtration, obtains white solid；Again with acetone, n-hexane recrystallization；Obtain target product Irbesartan impurity A. |
| priorityDate | 2013-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.