| abstract |
The invention discloses a method for preparing levetiracetam intermediate 2-aminobutyric acid represented by formula (III): firstly, in the first pipeline reactor, the raw material butyric acid is reacted with chlorine gas in the presence of a catalyst, Obtain the 2-chlorobutyric acid shown in formula (II); Then in the second pipeline reactor, 2-chlorobutyric acid is ammoniated in the presence of ammonium chloride and sodium hydroxide aqueous solution to obtain the formula (III) The 2-aminobutyric acid shown; the method of the present invention has high atom economy, few by-products, simple and convenient operation, and is suitable for industrial production. |