| abstract |
The invention discloses the synthetic method of the arylalkyl thioethers compounds shown in a kind of formula (II), is in reaction solvent, with aryl amine derivatives and halogenated alkane for reaction raw materials, with Nan 2 sn 2 on 3 for sulfiding reagent, under α-benzoinoxime catalyst action, be obtained by reacting arylalkyl thioethers compound.Synthetic method raw material of the present invention is easy to get inexpensive, operation is simple, reaction conditions is gentle, productive rate is higher, functional group tolerance is outstanding, and successfully achieve the later stage modification of the compounds such as medicine, sugar, amino acid, for pharmaceutical chemistry, bio-orthogonal chemical research provide the method for efficiently constructing carbon-sulfur bond. |