http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103772463-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 |
| filingDate | 2013-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103772463-B |
| titleOfInvention | 2ME2 analog and preparation method thereof and purposes |
| abstract | The present invention relates to 2ME2 analog and preparation method thereof and purposes, can effectively solve the preparation of 2ME2 analog and realize the application in preparing antitumor drug of the 2ME2 analog, method is, with 2-methoxyl group-3-benzyloxy-female steroid-1, 3, 5 (10)-triolefin-17 β-ol or 17 β-amine are raw material, it is dissolved in organic solvent, under Lewis alkali exists, carry out acylation reaction with compound (1) obtain 2-methoxyl group-3-benzyloxy-female steroid-1, 3, 5 (10)-triolefin-17 β-ester or 17 β-amide compound (2), then catalyzed hydrogenation reaction obtains compound (3), finally obtain compound 2ME2 analog (4) then through acylation reaction or alkylation reaction, reaction equation is: The preparation method of 2ME2 analog of the present invention is simple, mild condition, and yield is high, can be effectively used for the exploitation of anti-tumor medicinal preparation。 |
| priorityDate | 2013-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 240.