http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103772432-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6512 |
| filingDate | 2014-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103772432-B |
| titleOfInvention | A kind of production method of benfotiamine |
| abstract | A production method for benfotiamine, take polyphosphoric acid as Phosphation reagent, reacts with VITMAIN B1, be hydrolyzed under having reacted rear high temperature, after being hydrolyzed, after the phosphoric acid by the mixing solutions extraction system of trioctylamine and organic solvent, directly add the phosphate monoester crude product of organic solvent liberating vitamin B1.The crude product obtained, without purification, directly with water making beating, after adjusting pH value, reacts with Benzoyl chloride, filtering solids with liquid caustic soda.Filtrate adjusts pH value to 3.5 ~ 4.0 to separate out solid, is separated and dries to obtain white solid, is benfotiamine.The benfotiamine productive rate obtained by this explained hereafter is high, and product purity is high, simple to operate, environmentally friendly, is applicable to suitability for industrialized production. |
| priorityDate | 2014-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.