http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103772412-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-06 |
| filingDate | 2012-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103772412-B |
| titleOfInvention | A kind of preparation method of Pazufloxacin intermediate |
| abstract | The present invention relates to a kind of preparation method of Pazufloxacin intermediate.Described preparation method is: under suitable solvent and suitable temp, Compound II per under mineral alkali and phase-transfer catalyst effect with 1,2-ethylene dichloride carries out cyclopropanization reaction, then be hydrolyzed the backflow of this reaction system direct heating reaction, obtains described Pazufloxacin midbody compound IV through aftertreatment; The weight ratio of described mineral alkali and described Compound II per is 1.5 ~ 2.5:1; The ratio of described solvent and described Compound II per is 14 ~ 16mL:1g.Compared with prior art, in preparation method of the present invention, adopt the alkali of certain concentration and specified quantitative, adopt " one kettle way " to carry out two-step reaction thus, simplify unit operation; And the three wastes produced in preparation process are few, environmental protection pressure is little, and yield is high, is suitable for suitability for industrialized production. |
| priorityDate | 2012-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.