| abstract |
The present invention provides a drug conjugate. The conjugate comprises a protein-based recognition molecule ( PBRM ) and a polymeric carrier substituted by one or more ‑LD‑Ds, to which the protein-based recognition molecule is linked via LP . Each occurrence of D is independently a therapeutic agent having a molecular weight < 5 kDa. LD and LP are linkers that attach the therapeutic agent and PBRM to the polymeric carrier, respectively. The present invention also discloses polymeric scaffolds for conjugation with PBRMs to form polymer-drug-PBRM conjugates as described herein, compositions comprising the conjugates, methods for their preparation, and use of the conjugates or a combination thereof for the treatment of various conditions. |