http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103735550-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-205 |
| filingDate | 2013-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103735550-B |
| titleOfInvention | A kind of pharmaceutical composition and application thereof for the treatment of chronic kidney disease myocardial damage |
| abstract | The present invention relates to a kind of pharmaceutical composition and application thereof for the treatment of chronic kidney disease myocardial damage.Described pharmaceutical composition contains levocarnitine and trimetazidine, and the weight ratio of levocarnitine and trimetazidine is (77-81): 1, preferred 80:1, and it is also containing conventional pharmaceutical carrier.The present invention by different proportion levocarnitine and trimetazidine coupling under the specific dosage of research for the CKD rat heart, renal function and tissue pathologies change, and it is on the impact of energy metabolism of myocardial, find levocarnitine, trimetazidine weight ratio is at (77-81): plump to CKD rat left ventricle rear wall in the scope of 1, it is the most obvious that Myocardial Interstitial Fibrosis improves effect, the energy metabolism of CKD rat heart muscle significantly improves, inflammation, oxidative stress also significantly improves, heart pathological score and Pathological GSI, TIS scoring significantly declines, thus significantly reduce chronic kidney disease myocardial damage. |
| priorityDate | 2013-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.