| abstract |
The present invention relates to bisbenzimidazole bicarbazole compounds, in particular to the application of bisbenzimidazole bicarbazole compounds in specific binding to nucleic acid G-quadruplex structure and the application in antitumor drugs. In the present invention, the dibenzimidazole-carbazole compound is incubated with the nucleic acid sample to be tested in a buffer solution with a pH value of 6-8, and the absorption peak of the ultraviolet-visible absorption spectrum in the range of 390-440nm is significantly enhanced, Or observe whether a fluorescence peak appears in the range of 430-540 nm in the fluorescence spectrum to detect whether the nucleic acid sample to be tested is a nucleic acid with a G-quadruplex structure. The dibenzimidazole bicarbazole compound is added into the culture solution containing tumor cells as a drug, and cultured with the tumor cells to inhibit the proliferation of the tumor cells; or used as the main active ingredient of the drug to inhibit the proliferation of the tumor cells. The method of the invention has the advantages of simplicity, quickness and low cost. |