http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103724326-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2013-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103724326-B |
| titleOfInvention | A kind of preparation method of High-purity fasudil hydrochloride |
| abstract | The invention discloses a kind of preparation method of High-purity fasudil hydrochloride, the method be with homopiperazine and isoquinoline 99.9-5-sulfonyl chloride hydrochloride for raw material, use anhydrous alcohol solution homopiperazine; Methylene dichloride dissolves isoquinoline 99.9-5-sulfonyl chloride hydrochloride, and add anhydrous sodium sulphate and solid sodium bicarbonate, reacted by homopiperazine ethanolic soln and isoquinoline 99.9-5-chloride solution, repeatedly concentrating under reduced pressure crystallization, eventually pass filtration, dry obtained High-purity fasudil hydrochloride.The Fasudil Hydrochloride foreign matter content utilizing the inventive method obtained is lower than 0.1%, and purity reaches more than 99.9%.The advantages such as this preparation method has safety, environmental protection, production cost is low, quality product is high, easy to operate. |
| priorityDate | 2013-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.