| abstract |
The invention belongs to the pharmaceutical chemistry and chemical synthesis field, and more specifically belongs to the pharmaceutical chemistry and chemical synthesis field. The invention relates to (2R)-2-desoxy-2,2-disubstituted-1,4-ribonolactones with a single configuration, a preparation method and a purpose thereof. The invention provides the (2R)-2-desoxy-2,2-disubstituted-1,4-ribonolactones shown in a following general formula V, its pharmaceutically acceptable salt, ester, the prodrug or the solvate are important intermediates of a plurality of antiviral and antineoplastic active components. A compound expressed by a general formula VI and obtained by an acylation reaction of the compound expressed by the general formula V can be directly used for preparing a plurality of antiviral and antineoplastic medicines. The provided chiral synthetic method and crystallization separation method of the compound expressed by the general formula V have the following advantages of short route, simple method, high yield and low cost, and is adapted to industrial production. (img file='DDA00002237929500011.TIF' wi= '313' he='235'/). |