http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103717609-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6584 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6584 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-32 |
| filingDate | 2012-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103717609-B |
| titleOfInvention | Tricyclic inhibitors of poly(ADP-ribose) polymerase |
| abstract | The present invention provides compositions comprising phosphorus-containing tricyclic compounds, including phthalazin-1(2H)-one derivatives. This compound is a potent inhibitor of poly(ADP-ribose) polymerase (PARP), especially PARP-1 and potentially PARP-2, which also shows good cellular activity in inhibiting poly(ADP-ribose) oligomer formation. These compounds are useful as monotherapy or in combination with other therapeutic agents in the treatment of PARP-associated diseases such as cancer, inflammatory diseases and ischemic diseases. Accordingly, the present invention also provides a method of treating a PARP-associated disease comprising administering to an individual in need thereof an effective amount of a compound of the present invention. |
| priorityDate | 2011-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 950.