http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103705515-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-155 |
| filingDate | 2013-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103705515-B |
| titleOfInvention | The preparation method of the pharmaceutical composition that contains Repaglinide and Metformin hydrochloride |
| abstract | The invention provides a kind of preparation method of the pharmaceutical composition that comprises active component Repaglinide and Metformin hydrochloride, described pharmaceutical composition contains Repaglinide and Metformin hydrochloride and pharmaceutically acceptable excipient, and described preparation method comprises the following steps: by high shear mixing granulator, Repaglinide is mixed with melbine; And by one-step palletizing technology, binder solution is directly sprayed in Repaglinide and melbine composition and granulated, then be prepared into tablet after adding partial supplementary material. Beneficial effect of the present invention: the present invention can ensure the dissolution rate that Repaglinide has good homogeneity and not affected by pH value, improved the problem of Metformin hydrochloride poor compressibility simultaneously, process stabilizing, particle homogeneous, good fluidity, what solved low specification Repaglinide and high standard melbine mixes homogeneity problem and dissolution rate problem. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018034627-A1 |
| priorityDate | 2013-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.