http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103695447-B
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-52 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P37-04 |
filingDate | 2013-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2015-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2015-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-103695447-B |
titleOfInvention | A kind of novel lactam antibiotics synthetic enzyme and encoding gene thereof and application |
abstract | The invention discloses a kind of novel lactam antibiotics synthetic enzyme; according to achromobacter CCM4824 penicillin acylase aminoacid sequence (Genebank:AY919310.1) in Genebank, there is the sudden change at least one site following: the 184th asparagus fern acyl acid replaces with tyrosine, the 330th phenylalanine replaces with L-Ala, the 415th Methionin replaces with arginine, the 454th leucine replaces with L-Ala, the 623rd aspartic acid replaces with l-asparagine, the 770th leucine replaces with phenylalanine, the 790th glycine replaces with L-Ala.The invention also discloses the described Optimized Coding Based gene of novel lactam antibiotics synthetic enzyme, the recombinant vectors containing this encoding gene and recombinant bacterial strain and the application of this enzyme in synthesis amoxycilline Trihydrate bp, Cephalexin Monohydrate Micro/Compacted, cefaclor synthesis.This enzyme as the synthesis enzyme of the lactam antibioticses such as amoxycilline Trihydrate bp, Cephalexin Monohydrate Micro/Compacted, cefaclor, have that composite reactive is high, substrate conversion efficiency is high, side chain than the advantage such as low, to be widely used, there is good industrial applications prospect. |
priorityDate | 2013-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.