http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103694248-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-352 |
| filingDate | 2013-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103694248-B |
| titleOfInvention | Antitumor compound extracted from guttifer, and preparation method and application thereof |
| abstract | The invention relates to an antitumor compound extracted from guttifer, and a preparation method and application thereof. The preparation method of the compound comprises the following steps: (1) taking the medicinal material guttifer, extracting with ethyl acetate, carrying out silica gel column chromatographic separation on the extract, and carrying out petroleum ether-ethyl acetate gradient elution to obtain 11 components A-K; (2) discarding the grease components and garcinia acid components, carrying out HPLC-PDA-MS (high performance liquid chromatography-potato dextrose agar-Murashige-Skoog) repeat analysis to obtain a key component I; (3) carrying out silica gel column chromatographic separation on the component I, carrying out chloroform-methanol gradient elution to obtain a fraction I-2, collecting one fraction for every 30ml, and merging identical components according to the TLC (thin layer chromatography) result to obtain a fraction I-3; (4) carrying out reversed phase RP-18 separation on I-3, carrying out acetonitrile-water gradient elution, collecting one fraction for every 20ml, and merging identical components to obtain a subfraction I-3E; and (5) carrying out purification and acetonitrile elution on I-3E to obtain the compound. The compound can be used for treating tumors. |
| priorityDate | 2013-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.