| abstract |
The invention discloses an aromatic heterocyclic small molecule organic compound and its derivatives shown in structural formula (I), or a hydrate or a pharmaceutically acceptable salt, and a preparation method for the corresponding compound. The invention also discloses The application of the compound and the pharmaceutical composition containing the compound in the treatment of various metabolic syndrome and other related diseases. The aromatic heterocyclic small molecule organic compound proposed by the present invention has an excellent therapeutic effect on metabolic syndrome, and the experimental results show that this type of compound may promote the secretion of endogenous GLP-1, and is suitable for the preparation of candidate drugs for anti-diabetes and weight loss . Aiming at the technical problems such as easy degradation and short half-life of the existing drugs for treating diabetes, the present invention proposes a new type of high-efficiency small molecule compound that promotes the secretion of endogenous GLP-1, which can be used to treat metabolic syndrome such as diabetes and obesity. symptom-related diseases. |