http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103694145-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C277-08 |
| filingDate | 2013-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103694145-B |
| titleOfInvention | The synthetic method of (2-methyl-5-nitrophenyl) guanidine sulfate |
| abstract | The invention belongs to medicine intermediate technical field, particularly the synthetic method of a kind of imatinib mesylate intermediate (2-methyl-5-nitrophenyl) guanidine sulfate.With 2-amino-4-nitrotoluene and oxygen Methyl Isourea Sulfate for raw material, in ethanol and DMF, react under alkaline condition, then through acid adjustment, suction filtration, (2-methyl-5-nitrophenyl) guanidine sulfate.Adopt oxygen Methyl Isourea Sulfate to replace cyanamide to react, raw material is easy to get, and reaction conditions is simple, and be not difficult to the by product processed, product purity is high, and high purity more than 99.7%, yield is high. |
| priorityDate | 2013-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.