http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103690560-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-12 |
| filingDate | 2013-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103690560-B |
| titleOfInvention | A kind of Invert sugar electrolyte injection pharmaceutical composition and preparation method thereof |
| abstract | The present invention relates to a kind of Invert sugar electrolyte injection pharmaceutical composition that improve stability and preparation method thereof.Said composition is containing fructose, glucose, sodium lactate, sodium chloride, potassium chloride, magnesium chloride, sodium dihydrogen phosphate, sodium sulfite and gluconic acid.Its preparation method includes drug solution preparing, activated carbon adsorption, circulation takes off charcoal, gluconic acid adjusts pH value, embedding, lamp inspection, packaging and other steps.The present invention utilizes the phosphatic strong buffer capacity of gluconic acid and gluconic acid and Fe 3+ Deng the chelation of metal ion, the Invert sugar electrolyte injection pharmaceutical composition making the present invention prepare can keep stable pH scope in high temperature sterilize, and in the range of this pH, glucose, fructose are difficult to dehydration and generate 5 Hydroxymethylfurfural；Meanwhile, by the Fe brought in environment 3+ Deng metal ion owing to being chelated, its catalytic action in the side reaction producing 5 Hydroxymethylfurfural is greatly diminished, thus has efficiently controlled 5 Hydroxymethylfurfural in injection and had the content of related substance, improves the safety of product quality and medication. |
| priorityDate | 2013-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 151.