http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103664991-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 2012-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103664991-B |
| titleOfInvention | Thiophene [2,3 d] pyrimidine derivatives, Its Preparation Method And Use |
| abstract | The present invention provides the thiophene containing isoxazole heterocycle [2, the 3 d] pyrimidine derivatives shown in a kind of formula (I), or its pharmaceutically acceptable salt, wherein R 1 And R 2 It is each independently selected from hydrogen, C 1‑6 Alkyl, C 1‑6 Alkoxyl, halo C 1‑6 Alkyl or halo C 1‑6 Alkoxyl, optionally by R 7 Substituted aryl or optionally by R 8 Substituted heteroaryl；Or R 1 And R 2 Coupled carbon atom forms 4 to 6 yuan of carbocyclic rings or heterocycle together；Z is NR 5 ‑,C(R 6 ) 2 , S or O；R 3 Selected from hydrogen, halogen, C 1‑6 Alkyl, C 1‑6 Alkoxyl, halo C 1‑6 Alkyl or halo C 1‑6 Alkoxyl, n is the integer of 0～5;R 4 Selected from hydrogen, C 1‑6 Alkyl, C 1‑6 Alkoxyl or halo C 1‑6 Alkyl, optionally by R 9 Substituted aryl or optionally by R 10 Substituted heteroaryl.The present invention also provides for formula (I) compound and the preparation method of its pharmaceutically acceptable salt and medical usage, and this compounds can be as the medicine of the treatment disease such as tumor, cancer or lead compound. |
| priorityDate | 2012-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 140.