http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103664952-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2012-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103664952-B |
| titleOfInvention | A kind of preparation method of Zopiclone |
| abstract | The present invention relates to a kind of preparation method of the Zopiclone for improving water flood, belong to field of medicaments.The present invention is at 6-(5-chloro-2-pyridyl)-5,7-dioxy-5,6-pyrrolin also [3,4-b] pyrazine, namely in compound 3 preparation process, take DMAP as catalyzer, directly cyclization intermediate 3 can be generated under triethylamine exists, crude yield 85%, not only yield improves, and simplifies the operation, and avoid using the pungency reagent such as diacetyl oxide, sulfur oxychloride, Vinyl chloroformate stimulated, be conducive to producing, solvent xylene is beneficial to recovery, decreases the discharge of the three wastes.Utilize compound 3 to synthesize Zopiclone further, whole piece route is brief, easy and simple to handle, is more suitable for suitability for industrialized production. |
| priorityDate | 2012-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.