| abstract |
The present invention generally relates to antigen-specific immunoconjugates for the selective delivery of effector moieties that affect cellular activity. More specifically, the present invention provides novel immunoconjugates comprising a first antigen binding moiety, an Fc domain and a single effector moiety. In addition, the present invention relates to polynucleotides encoding such immunoconjugates, as well as vectors and host cells comprising such polynucleotides. The invention also relates to methods for producing the immunoconjugates of the invention, and methods of using these immunoconjugates in the treatment of disease. |