http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103641917-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_09732f873ca8bfa73eae25f3dade1df1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_974372900d67116fd5a4e31f709109ae |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate | 2013-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2281baa55cac119d1bfdd066ae5e7b00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f5316e1e70165a7aa79fc4238e24c44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be2926f6050ccd3705a534c8f2460bc2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c7567f6ae6c3c25fa0b022b0aa9dc78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5859cca240824cd86a6457ede8881e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_807f134d8d458e71e6967c1635439801 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0258286325ba4a477d622e1820b01481 |
| publicationDate | 2015-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103641917-B |
| titleOfInvention | Anti-CD26 antibody and application thereof |
| abstract | The invention provides a novel full-humanized antibody which is high in affinity and can be specifically combined with CD26, and a preparation method and application thereof, and belongs to the technical field of a genetically engineered antibody. CD26 is a ubiquitous multifunctional II-type transmembrane glycoprotein, has a plurality of biological functions, and can interact with a plurality of proteins, such as ADA, CD45, FAP-alpha and the like. The invention provides an antibody from a human source or a segment thereof. The antibody or the segment thereof is specifically combined with human CD26, and preferably specifically combined with a CD26 extracellular region; an amino acid sequence of the antibody or the segment thereof comprises a monoclonal antibody which is selected from any region of six complementary determining regions containing a group of sequences of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:7 and SEQ ID NO:8, or a segment thereof or a conjugate of the segment thereof, or an amino acid sequence which is obtained by amino acid replacement or modification. The anti-CD26 single-chain antibody obtained by the method is highly specifically combined with the CD26, and meanwhile, multiplication of tumor cells can also be obviously inhibited. |
| priorityDate | 2013-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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