http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103641697-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a3d7e466c44c7b54e2a48e4bf62665ef |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-353 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-29 |
| filingDate | 2013-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66f2d1c1b7c85e0c7326dda6c550efb8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_876656f47b858352f99dbee8cb97f72d |
| publicationDate | 2015-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103641697-B |
| titleOfInvention | Preparation method of medical intermediate 1-(3-iodopropyl)-3-phenoxy benzene |
| abstract | The invention relates to the field of medical chemistry, and in particular relates to a method for preparing 1-(3-iodopropyl)-3-phenoxy benzene by condensing, esterifying, reducing and iodinating 3-phenoxybenzaldehyde and propane diacid. The method comprises the following steps: preparing 3-(triphenoxy phenyl)-2-acrylic acid by condensing 3-phenoxybenzaldehyde and propane diacid under the catalysis of an organic base, esterifying and reducing to obtain 3-(3-triphenoxy phenyl)-1-propanol, and then iodinating to prepare the 1-(3-iodopropyl)-3-phenoxy benzene. The reaction is mild, the potassium iodide is used as a cocatalyst in the iodination process, the reaction yield is improved, and the total yield of the reaction can achieve 50%; the sodium borohydride is used as a reducing agent in the preparation process, PEG (Polyethylene Glycol) is used as a solvent, the potential safety hazard caused by an unsafe potential reagent such as lithium aluminum hydride in the existing document is solved, the process is concise, and the method is suitable for large-scale popularization and application. |
| priorityDate | 2013-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.