http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103637990-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 |
| filingDate | 2013-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103637990-B |
| titleOfInvention | The preparation method of folacin coupled chitosan-mitoxantrone hydrochloride nanoparticle |
| abstract | The present invention relates to antineoplastic target technical field of pharmaceuticals, be specifically related to the preparation method of folacin coupled chitosan-mitoxantrone hydrochloride nanoparticle, it comprises the following steps: step one, mitoxantrone hydrochloride solution is mixed with chitosan-acetic acid solution, obtains chitosan and mitoxantrone hydrochloride mixed liquor; Step 2, joins chitosan and mitoxantrone hydrochloride mixed liquor in folic acid ammonia saline solution, then continues to add polyphosphoric acids sodium water solution, mix homogeneously in folic acid ammonia saline solution, obtains folic acid-chitosan-mitoxantrone hydrochloride aqueous microsphere dispersion system; Step 3, is undertaken folic acid-chitosan-mitoxantrone hydrochloride aqueous microsphere dispersion system being centrifugally precipitated thing, carries out lyophilization, obtain folacin coupled chitosan-mitoxantrone hydrochloride nanoparticle after being washed by precipitate.This preparation method avoids the use of organic solvent, substantially reduces the time of reaction, and obtained nanoparticle has obvious targeting to tumor cell, and good biocompatibility. |
| priorityDate | 2013-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.