http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103623430-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5456846495c5fa8a02f5eaae9faae290 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2013-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b33dcf47d25504e1dcaaf440759a3028 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d63a64fb870c6fda6d358edf6344e7ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e318327178b234a0c4a9d5204539efe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f89bb0ba22f3962b7c872238920bd887 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_beada6da5d95ea94d88b6cbbdd4d8efe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_729c05c417a2308e5e0b6a752e0d7ec9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7361c38e4a958386c1e9c1dc926beb67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e23f1eaa84603457a476e4a84059ff8 |
| publicationDate | 2015-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103623430-B |
| titleOfInvention | Preparation method and application of targeted co-supported drug delivery system nano-particles based on polylactic-co-glycolic acid |
| abstract | The invention relates to a preparation method and application of targeted co-supported drug delivery system nano-particles based on polylactic-co-glycolic acid (PLGA), which can effectively solve the problem of preparing the targeted co-supported drug delivery system nano-particles based on polylactic-co-glycolic acid, and realizes the application in cerebral tumor targeted treatment medicines. The method comprises the following steps: connecting Angiopep-2 by utilizing the reactive amino group on chitosan: reacting chitosan with 3-maleimidopropionic acid N-hydroxysuccinimide to enable the amino terminal of chitosan to have maleimide; reacting with terminal-sulfhydrylated Angiopepe-2 to obtain a chitosan-angiopep-2 polymer. The polymer can be applied to preparation of a PLGA-based targeted co-supported drug delivery system. The method is stable and reliable, the product has a good using effect, small-molecular chemical drugs and genetic drugs can be delivered at the same time, or a fluorescent probe can pass through a blood brain barrier and enters the brain while chemotherapeutic drugs are delivered, and targeted cerebral tumor treatment can be synergized or targeted cerebral tumor treatment and diagnosis can be integrated into a whole. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021255492-A1 |
| priorityDate | 2013-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 116.