http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103613562-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-60 |
| filingDate | 2013-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103613562-B |
| titleOfInvention | A kind of preparation method of pramipexole |
| abstract | The invention discloses a kind of preparation method of pramipexole; 4-Trans-4-Amino Cyclohexanol is adopted to be starting raw material; described pramipexole is obtained successively through acidylate, oxidation, alpha-halogen, Guan Huan, hydrolysis, fractionation, propionating and reduction reaction; the pramipexole obtained can further with hydrochloric acid generation salt-forming reaction, obtain pramipexole hydrochloride through aftertreatment after reacting completely.In this reaction scheme, the oxidizing reaction of step (2) adopts cheap TCCA (Trichloroisocyanuric acid) to replace CrOn 3 as oxygenant, both reduce cost, solve pollution problem again; The reduction reaction of step (7) adopts sulfuric acid and sodium borohydride as reductive agent, both reduces cost, and turn improves the quality of product, and had important industrial application value. |
| priorityDate | 2013-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 84.