http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103601808-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate | 2012-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103601808-B |
| titleOfInvention | Sodium peptide, preparation method and preparing the application in genetically engineered drug |
| abstract | The invention discloses a kind of sodium peptide, this sodium peptide is connected to form by brain natriuretic peptide and snake sodium peptide; Brain natriuretic peptide is positioned at the N end of sodium peptide, and snake sodium peptide is positioned at the C end of sodium peptide; Wherein, brain natriuretic peptide comprises the disulfide linkage ring texture formed by two cysteine residues.Its preparation method comprises: obtain brain natriuretic peptide gene and snake sodium peptide gene, by PCR method splicing synthesis sodium peptide gene; Build the expression plasmid comprising sodium peptide gene; Expression plasmid is converted in suitable expression strain and carries out inducing culture, the expression of induction sodium peptide.Sodium peptide of the present invention has the characteristic of brain natriuretic peptide and snake sodium peptide simultaneously, and specific effect significantly strengthens, and drug half-life obviously extends; Preparation method's technique of the present invention is simple, practical; The genetically engineered drug with sodium peptide can the effector such as useful effect heart, blood vessel and kidney, and the diseases such as the function of the above-mentioned organ of available protecting, prevention and therapy heart and kidney failure. |
| priorityDate | 2012-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 150.