| abstract |
The invention discloses a preparation method of milnacipran hydrochloride, which is obtained by reducing the compound V of the following formula in an inert solvent and then forming a salt. The present invention utilizes existing compound I to undergo five-step reactions to generate compound V, and then reduces compound V to form a salt to obtain milnacipran hydrochloride. Each step of reaction is simple in operation, mild in conditions, and has high yields of intermediates and final products. The method has high purity, provides an economical and efficient method for preparing milnacipran hydrochloride, and is suitable for industrial production. |