http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103599548-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 |
| filingDate | 2013-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103599548-B |
| titleOfInvention | A kind of taxol polymer bond drug and preparation method thereof |
| abstract | The invention provides a kind of taxol polymer bond drug, comprise containing the polymer of end carboxyl and the paclitaxel with the described polymer esterification bonding containing end carboxyl; The preparation method of the described polymer containing end carboxyl is: with poly glycol monomethyl ether or Polyethylene Glycol for initiator, the ring-opening polymerisation under catalyst action of aliphatic cyclic ester monomer, obtains amphipathic nature polyalcohol; By described amphipathic nature polyalcohol with containing the diacid of disulfide bond under organic base and condensing agent effect, react in the first organic solvent, obtain the polymer containing end carboxyl.Described taxol polymer bond drug improves the dissolubility of paclitaxel in water, there is reduction-sensitive, micelle can be self-assembled into, there is good hydrophilic and biocompatibility, human body reticuloendothelial system phagocytic in blood circulation can be avoided, ensure the sufficient time by EPR effect arrival tumor locus, and then enter cell by endocytosis, realize the efficient targeting of medicine. |
| priorityDate | 2013-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.