| abstract |
A system for multiphase delivery of at least one growth factor at a treatment site, comprising a delivery vehicle for releasing at least one growth factor in an initial release profile, and for releasing at least one growth factor in a sustained release profile growth factor carrier. The initial release profile releases at least one growth factor over a period of hours to days, wherein the growth factor is initially released in large amounts and the remainder is released in gradually decreasing amounts. Sustained release modes release at least one growth factor over a period of days to weeks, wherein the growth factor is released in a generally constant amount over such time period. The system of the present invention is particularly suitable for application to biological implants. The present invention also includes methods and kits for the multiphase delivery of at least one growth factor. |