http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103589730-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-66 |
| filingDate | 2013-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103589730-B |
| titleOfInvention | A kind of shRNA and application suppressing IRS1 genetic expression |
| abstract | The invention discloses a kind of shRNA and the application that suppress IRS1 genetic expression, belong to gene engineering technology field.The nucleotide sequence of shRNA provided by the invention is as SEQ ID NO.1.By being connected with the plasmid vector with IRS2 gene, present invention also offers and a kind of there is the shRNA interference carrier simultaneously striking low pig source IRS1 and IRS2 genetic expression.The result display of porcine hepatocyte cells IRS gene expression experiment, shRNA interference carrier is respectively by the IRS1 gene of pig and IRS2 Knockdown 78% and 64%.Meanwhile, the low glycolipid metabolism to porcine hepatocyte cells that strikes of IRS gene expression dose has an impact, and improves the blood sugar concentration of porcine hepatocyte cells.The present invention is not only structure diabetes B swine model and lays the foundation, and also to how improving pig blood sugar concentration benefits our pursuits. |
| priorityDate | 2013-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 278.