http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103588820-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-24 |
| filingDate | 2013-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103588820-B |
| titleOfInvention | A kind of folic acid-nickel ligand polymer nanotube and preparation method thereof and application |
| abstract | The invention provides a kind of folic acid-nickel ligand polymer nanotube, its chemical formula is Nin 2 (FA) (Nn 2 hn 4 )n 3 (Hn 2 o)n 2 (OHn - )n 2 .Wherein, described folic acid-nickel ligand polymer nanotube forms title complex by nickel ion, folic acid and hydrazine hydrate, the bridge linking effect of the hydrogen bond between folate molecule and hydrazine hydrate molecule forms nanotube, and the length of described folic acid-nickel ligand polymer nanotube is 50 ~ 300nm, internal diameter is 5 ~ 8nm, wall thickness is 4 ~ 7nm.This folic acid-nickel ligand polymer nanotube (CPNTs) self has good anti tumor activity in vitro, and there is larger cavity can the polytype antitumor drug of physical loading, can specific recognition surface have high-level folacin receptor express cell, there is potential application prospect in neoplasm targeted therapy. |
| priorityDate | 2013-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.