http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103588755-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d7e2f8fb5650d7d3616661464b67771 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_978c7911295fd025d643a702ac408769 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2012-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb735103a93b7efbe1e02065a7a8249b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42bc9418dd253cf1a03aef2df5216592 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6928f3573d335a697956b30474069260 |
| publicationDate | 2014-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103588755-A |
| titleOfInvention | The preparation method of Neratinib |
| abstract | The present invention relates to the preparation method of Neratinib, in particular to N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy -6-quinolinyl]-2-phosphate diethyl ester-acetamide and dimethylaminoacetaldehyde ethylene acetal or 2-dimethylaminoacetaldehyde, in the presence of lithium salt and base, react to generate Neratinib. The method of the invention has high yield and mild reaction conditions, and the reagents used are commonly used commercially available reagents with low price, is more suitable for industrial production, and has good economic prospects. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113121512-A |
| priorityDate | 2012-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 18.