| abstract |
The present invention provides inhibitors of focal adhesion kinases, which are enzymes involved in the association of the cytoskeleton of cells with the extracellular matrix, which are involved in processes such as cell migration, cell proliferation, and cell survival. The inhibitor is a 5-substituted 2,4-diaminopyridine derivative, wherein the substituents are as defined herein. The invention also provides a method for using the inhibitor to treat cancer and a method for preparing the inhibitor through a coupling reaction. |