http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103588699-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9961cb812895d1f8c98c137c534f36d7 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-56 |
| filingDate | 2012-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cce27ae683a9a0c2288da0f551cc048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a8937243d19198db905c1ccb1d49016 |
| publicationDate | 2014-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103588699-A |
| titleOfInvention | Asymmetric Synthesis of (R)-3-Aminopiperidine (I) and Related Intermediates |
| abstract | The present invention relates to an asymmetric synthesis method of (R)-3-aminopiperidine (I), which is to reduce the compound of formula (III) to obtain the compound of formula (II), and then remove the compound of formula (II) A group and an amino protecting group give (R)-3-aminopiperidine (I), Wherein, R is an amino protecting group, especially a C1-4 alkoxycarbonyl group or benzyl group which can be removed by hydrolysis or hydrogenation. Preferably, the compound of formula (III) is obtained by the dehydration reaction of 3-piperidone and chiral amine (R)-1-phenethylamine. The present invention also relates to novel compounds (II). The asymmetric synthesis method of (R)-3-aminopiperidine (I) of the present invention has reasonable process, simple route, and obtains the desired product with a higher ee value by using chiral induction, and the raw materials are cheap, no need for resolution, and the realization In order to avoid the discharge of waste isomers, it is suitable for large-scale industrial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105111134-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107677735-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015139332-A1 |
| priorityDate | 2012-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.