| abstract |
This application discloses the compound according to general formula (I), wherein all variablees define as described herein, and described compound suppresses Btk.Compound disclosed herein may be used for the disease regulating the activity of Btk relevant to excessive Btk activity with treatment.Described compound can also be used for the treatment of to breed relevant inflammatory and autoimmune disease as rheumatoid arthritis to aberrant B cell.Also disclose the composition containing formula I and at least one carrier, thinner or vehicle. |