http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103571458-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2832a40f112f92bf8d7655e3809f5815 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 |
| filingDate | 2012-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db176a89d2ff3208fd8d74db969adcee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73a909c716a5d31c4298349a0a9ee0c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9b06488983f53f2802060dec77d12e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4db50ddd7751e344685778b38ca50ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20ffe604478002581781fbc1e1573856 |
| publicationDate | 2015-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103571458-B |
| titleOfInvention | Selenium-containing fluorine-boron dye fluorescent probe and application thereof in ClO<-> detection |
| abstract | The invention discloses synthesis of a selenium-containing fluorine-boron dye fluorescent probe and application of the selenium-containing fluorine-boron dye fluorescent probe in ClO<-> detection, relates to a fluorescent probe of which the fluorescence intensity or a wavelength is changed under the existence of ClO<-> and is recovered under the existence of reducing substances and aims to realize reversible or rate detection of the ClO<->. The invention provides a reversible fluorescent probe for selectively detecting the ClO<-> in cells. According to the fluorescent probe, a fluorine-boron dye (BODIPY) is used as a fluorescent parent, and an organic selenide structure is introduced to the dye parent to form a probe system; selenium is used as an active center generating reaction with the ClO<->, so that the ClO<-> can be selectively detected; due to the characteristic that an organic selenium oxide formed by organic selenide oxidization is easily reduced into the organic selenide through reducing micromolecules such as cysteine, reduced glutathione and metallothionein in a biological system, reversibility of probe molecules is achieved. |
| priorityDate | 2012-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 113.