http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103570748-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a544c49cadf466ab6f2337003140df2e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-14 |
| filingDate | 2012-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e309717dd059bd1afca4311d04fabeb3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e16c4fdd00fbc0c96a675059f8276775 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2791db2eb1443ad20c59cd5c1e21567 |
| publicationDate | 2014-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103570748-A |
| titleOfInvention | Method for preparing telaprevir intermediate |
| abstract | The invention discloses a method for preparing a telaprevir intermediate. The method comprises the following steps: carrying out a ring-closure reaction between 2-cyclopentenone and a compound of a formula II in a mixed solvent system formed by an amide solvent and water according to a volume ratio of 1:1-3:1. According to the method, a solvent system in which the ring-closure reaction is carried out is changed, the mixed solvent system formed by the amide solvent and water according to a certain volume ratio is creatively adopted, the ring-closure product is separated out of the reaction system in a solid form, after the reaction is ended, only are the solids needed to be filtered and collected, and a target product with the high performance liquid chromatography (HPLC) purity of 97 percent can be obtained. The operations are greatly simplified, the yield is obviously increased, and the mole yield is increased from 20-30 percent in the prior art to be over 67 percent; the method is suitable for large-scale production, meets the large-scale industrial production requirement of telaprevir and has a high industrial application value. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104926831-A |
| priorityDate | 2012-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.