http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103570724-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2012-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103570724-B |
| titleOfInvention | The synthetic method of ponatinib |
| abstract | The invention discloses the synthetic method of a kind of ponatinib, this synthetic method is with imidazo [1, 2-b] pyridazine is that raw material and N-N-halosuccinimides are obtained by reacting 3-halogenated imidazole also [1, 2-b] pyridazine, the reaction of 3-iodo-4-R-benzoic ether generates the trimethyl silicon based acetylenylbenzene manthanoate of 4-R-3-, slough again and trimethyl silicon basedly obtain 3-ethynyl-4-R benzoic ether, 3-halogenated imidazole also [1, 2-b] pyridazine and 3-ethynyl-4-R benzoic ether be obtained by reacting 3-(imidazoles [1, 2-b] pyridazine-3-ethyl-acetylene base)-4-R benzoic ether, product and 4-((4-methylpiperazine-1-yl) methylene radical)-3-5-trifluoromethylaniline are obtained by reacting ponatinib, above-mentioned R is methyl, ethyl, propyl group, sec.-propyl, normal-butyl, one in the tertiary butyl.This route technique is simple, and mild condition, product purity is high, and yield is high, and cost is lower, is beneficial to suitability for industrialized production. |
| priorityDate | 2012-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 85.