http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103570696-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 |
| filingDate | 2013-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103570696-B |
| titleOfInvention | A kind of preparation method of Axitinib intermediate and preparing the application in Axitinib |
| abstract | A kind of preparation method of Axitinib intermediate and intermediate are preparing the application in Axitinib, the preparation method of the iodo-6-nitro of a kind of Axitinib intermediate 3--1-(tetrahydrochysene-2H-pyrans-2-base)-1H-indazole: 6-nitro indazole under catalyst action with 3, 4-dihydro-2H-pyrans reacts, to blocking group tetrahydrochysene-2H-pyrans-2-base on N-H position, then Iod R on 3, obtain the key intermediate of high yield, intermediate is preparing the application in Axitinib: intermediate and 2-vinyl pyridine carry out Heck linked reaction, then in succession iodine in nitroreduction and diazotization reaction is carried out, finally docking deprotection again with 2-mercapto-N-methyl benzamide prepares Axitinib, the main starting material related to is all the raw material that market is easily bought, yield is high and molecule economical efficiency is high, it is a kind of high effective green environmentally friendly processing method, be applicable to industrialized production. |
| priorityDate | 2013-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.