http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103570641-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14d59bab55381ae2ec24d77119a68ddc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D267-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D267-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-54 |
| filingDate | 2013-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bc8c858458b460daf1c5be101c89272 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ff964ab96e0c3db3fb44a64516e41e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c5ddcbcda537e4a9a20b156ed516102 |
| publicationDate | 2014-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103570641-A |
| titleOfInvention | Preparation method of loxapine and key intermediate of loxapine |
| abstract | The invention belongs to the field of medicinal chemistry and discloses a preparation method of loxapine. The preparation method of loxapine comprises the following steps: in an organic solvent, carrying out a condensation reaction on a compound I and a compound II to obtain an intermediate III; carrying out a reduction condensation reaction on the intermediate III obtained in the step (1), so as to obtain an intermediate IV; carrying out a reaction on the intermediate IV obtained in the step (2) and N-methyl piperazine, so as to obtain a target compound TM. The loxapine is applied to acute short-term and long-term sustainable treatment of schizophrenia, and the preparation method of the loxapine has the advantages that the used reagent and raw materials are easy to get, yield and purity of the loxapine product are high and the preparation method of the loxapine is applicable to industrial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105418494-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105418494-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112409288-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112409288-B |
| priorityDate | 2013-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.